Lee A Dawson Selected Research

SB-616234-A

6/2006

Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity.

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Lee A Dawson Research Topics

Disease

14	Schizophrenia (Dementia Praecox) 01/2017 - 03/2005
4	Mood Disorders (Mood Disorder) 01/2009 - 06/2006
3	Catalepsy 01/2021 - 01/2007
3	Inflammation (Inflammations) 01/2020 - 01/2017
3	Memory Disorders (Memory Loss) 11/2009 - 04/2008
3	Cognitive Dysfunction 04/2008 - 02/2004
3	Mental Disorders (Mental Disorder) 01/2008 - 02/2004
3	Alzheimer Disease (Alzheimer's Disease) 06/2007 - 11/2003
2	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2021
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 02/2009 - 12/2008
2	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 05/2008 - 11/2007
2	Polydipsia 05/2008 - 11/2007
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Major Depressive Disorder (Major Depressive Disorders) 12/2013
1	Mania (Manias) 09/2011
1	Neurobehavioral Manifestations 01/2010
1	Psychotic Disorders (Schizoaffective Disorder) 01/2009
1	Substance-Related Disorders (Drug Abuse) 12/2008
1	Anxiety Disorders (Anxiety Disorder) 01/2008
1	Dementia (Dementias) 06/2007
1	Hypothermia 06/2006
1	Amyloid Plaque 11/2003

Drug/Important Bio-Agent (IBA)

4	Antipsychotic Agents (Antipsychotics)IBA 09/2013 - 01/2007
3	Neurokinin-3 ReceptorsIBA 02/2010 - 01/2008
3	Dopamine (Intropin)FDA LinkGeneric 01/2010 - 12/2008
3	Serotonin (5 Hydroxytryptamine)IBA 04/2008 - 05/2007
2	Haloperidol (Haldol)FDA LinkGeneric 01/2021 - 01/2009
2	LipopolysaccharidesIBA 01/2020 - 01/2017
2	Vilazodone HydrochlorideIBA 12/2013 - 01/2009
2	Antidepressive Agents (Antidepressants)IBA 12/2013 - 01/2008
2	LigandsIBA 09/2013 - 01/2010
2	Histamine H3 Receptors (Histamine H3 Receptor)IBA 01/2009 - 06/2007
2	serotonin 6 receptorIBA 12/2006 - 02/2004
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2021
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	InflammasomesIBA 01/2018
1	AMPA Receptors (AMPA Receptor)IBA 01/2017
1	EpitopesIBA 01/2017
1	Glycogen Synthase (Synthase I)IBA 09/2011
1	3-amino-N-(cyclopropyl (phenyl)methyl)- 2- (3- fluorophenyl)- 4- quinolinecarboxamideIBA 02/2010
1	GSK256471IBA 02/2010
1	TachykininsIBA 02/2010
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2010
1	Biological ProductsIBA 01/2010
1	Fluoxetine (Prozac)FDA LinkGeneric 11/2009
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 05/2009
1	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA 05/2009
1	Fumigant 93 (D-D)IBA 05/2009
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2009
1	5- ((3- cyclobutyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- yl)oxy)- N- methyl- 2- pyrazinecarboxamideIBA 01/2009
1	ProlactinIBA 01/2009
1	5-HT1A Serotonin ReceptorIBA 01/2009
1	Amphetamine (Amfetamine)FDA LinkGeneric 01/2009
1	Dopamine D2 Receptor AntagonistsIBA 01/2009
1	Serotonin Receptor Agonists (Serotonin Receptor Agonist)IBA 01/2009
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 12/2008
1	Peptides (Polypeptides)IBA 06/2008
1	SB 223412IBA 06/2008
1	N(1)- (6- chloroimidazo(2,1- b)(1,3)thiazole- 5- sulfonyl)tryptamineIBA 05/2008
1	Scopolamine (Hyoscine)FDA Link 04/2008
1	5-HT1 Serotonin ReceptorsIBA 01/2008
1	Ion Channels (Ion Channel)IBA 11/2007
1	gamma-Aminobutyric Acid (GABA)IBA 11/2007
1	6- ((3- cyclobutyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- yl)oxy)- N- methyl- 3- pyridinecarboxamideIBA 06/2007
1	AutoreceptorsIBA 05/2007
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 05/2007
1	Clozapine (Clozaril)FDA LinkGeneric 01/2007
1	1,2,3,4,8,9,10,10a- octahydro- 7bH- cyclopenta(b)(1,4)diazepino(6,7,1hj)indoleIBA 01/2007
1	indoleIBA 01/2007
1	Apomorphine FDA Link 01/2007
1	SB-616234-AIBA 06/2006
1	5-HT1B Serotonin ReceptorIBA 06/2006
1	Lysophosphatidic Acid ReceptorsIBA 03/2005
1	EnzymesIBA 11/2003

Therapy/Procedure

4	Therapeutics 01/2010 - 06/2006
1	Oral Administration 01/2021